- Health

Biologic therapy for psoriasis may reduce heart disease, reveals study | Health News

Dallas: Patients with psoriasis treated with biologic therapy, which are protein-based infusions to suppress inflammation, had a significant reduction in high-risk plaque in heart arteries, over one-year, according to new research. The research was published in Circulation: Cardiovascular Imaging, an American Heart Association journal.

Chronic inflammation in people with psoriasis is associated with a higher risk of developing coronary artery disease. Biologic therapy medications are proteins that are given by injection or infusion and suppress the inflammation process by blocking the action of cytokines, which are proteins that promote systemic inflammation.

Previous research has shown a clear link between psoriasis and the development of high-risk coronary plaque. 

This study provides a characterisation of a lipid-rich necrotic core, a dangerous type of coronary plaque made up of dead cells and cell debris that is prone to rupture. Ruptured plaque can lead to a heart attack or stroke.

“Having inflamed plaque that is prone to rupture increases the risk of heart attack five-fold within ten years,” said Nehal N Mehta, MD, MSCE, FAHA, study senior author, a Lasker Senior Investigator and chief of the Lab of Inflammation and Cardiometabolic Diseases at the National Heart, Lung, and Blood Institute at the National Institutes of Health in Bethesda, Maryland.

“This is the first time an imaging study in humans has shown what one year of ongoing, untreated inflammation can do to arteries of the heart and that we can reverse this damage. Untreated inflammation is dangerous. You are just waiting for a heart attack or stroke to happen,” Mehta said.

The analysis involved 209 middle-aged patients (ages 37-62) with psoriasis who participated in the Psoriasis Atherosclerosis Cardiometabolic Initiative at the National Institutes of Health, an ongoing observational study. Of these participants, 124 received biologic therapy, and 85 were in the control group, treated only with topical creams and light therapy. To measure the effects of biologic therapy on arteries of the heart, the researchers performed cardiac computed tomography (CT) scans on all study participants before they started therapy, and one year later. The CT results between the two groups were then compared.

At the start of the study, participants with psoriasis had low cardiovascular risk by conventional cardiovascular risk scores, and severe psoriasis was associated with higher body mass index (BMI), high-sensitivity C-reactive protein (a measure of systemic inflammation), and higher levels of coronary artery plaque. After one year of treatment, patients who received biologic therapy were compared to the control group. 
Researchers found: Biologic therapy was associated with an 8 per cent reduction in coronary plaque. In contrast, those in the control group experienced slightly increased coronary plaque progression. Even after adjusting for cardiovascular risk factors and psoriasis severity, patients treated with biologic therapy had reduced coronary plaque.

“There is approximately 6-8% reduction in coronary plaque following therapy with statins. Similarly, our treatment with biologic therapy reduced coronary plaque by the same amount after one year. These findings suggest that biologic therapy to treat psoriasis may be just as beneficial as statin therapy on heart arteries,” Mehta said.

This study has implications for people with psoriasis and possibly for people with other chronic inflammatory conditions such as HIV, lupus, and rheumatoid arthritis, who also have an increased risk of heart disease.

“We have never before been able to show healing of an inflamed plaque like this in humans. Biologic therapy reduces systemic inflammation and immune activation, and it has a favorable impact on improving overall vascular health. Imagine if we can treat both psoriasis and coronary heart disease with one therapy – that is the question to be asked in future studies,” Mehta said.

The study`s findings should be interpreted with caution because it was limited by a short follow-up period and a relatively small number of patients. Larger, randomized controlled studies are needed to better understand how changes in coronary plaque may lead to a reduction in heart attacks and strokes in people with psoriasis.

(function(d, s, id) {
var js, fjs = d.getElementsByTagName(s)[0];
if (d.getElementById(id)) return;
js = d.createElement(s); js.id = id;
js.src = “https://connect.facebook.net/en_US/sdk.js#xfbml=1&version=v2.9”;
fjs.parentNode.insertBefore(js, fjs);
}(document, ‘script’, ‘facebook-jssdk’));

(function ($) {
/*Drupal.behaviors.pagerload = {
attach: function (context, settings) {*/
$(document).ready(function(){
$(“.sidebar”).theiaStickySidebar();
/*$.get( “/hindi/zmapp/mobileapi/sections.php?sectionid=17,18,19,23,21,22,25,20”, function( data ) {
$( “#sub-menu” ).html( data );
alert( “Load was performed.” );
});*/
var nextpath=””; var pg = 1;
var nextload= true;
var string = ”;var ice = 0;
var playerFly;
var load = ‘

Loading

‘;
var cat = “?cat=120172”;
//$(“.main-rhs2309877″).theiaStickySidebar();
var instagram_script=document.createElement(‘script’);
instagram_script.defer=”defer”;
instagram_script.async=”async”;
instagram_script.src=”https://platform.instagram.com/en_US/embeds.js”;
document.head.appendChild(instagram_script);
/*************************************/
/*$(window).scroll(function(){
var last = $(‘div.listing’).filter(‘div:last’);
var lastHeight = last.offset().top ;
if(lastHeight + last.height() = 360) {
angle = 1;
}
angle += angle_increment;
}.bind(this),interval);
},
success: function(data){
nextload=false;
//console.log(“success”);
//console.log(data);
$.each(data[‘rows’], function(key,val){
//console.log(“data found”);
ice = 2;
if(val[‘id’]!=’2309877′){
string = ‘

‘ + val[“title”] + ‘

‘ + val[“summary”] + ‘

‘;
$(‘div.listing’).append(string);
}
});
},
error:function(xhr){
//console.log(“Error”);
//console.log(“An error occured: ” + xhr.status + ” ” + xhr.statusText);
nextload=false;
},
complete: function(){
$(‘div.listing’).find(“.loading-block”).remove();;
pg +=1;
//console.log(“mod” + ice%2);
nextpath=”&page=” + pg;
//console.log(“request complete” + nextpath);
cat = “?cat=120172”;
//console.log(nextpath);
nextload=(ice%2==0)?true:false;
}
});

}
//lastoff = last.offset();
//console.log(“**” + lastoff + “**”);
});*/
var maindiv = false;
var dis = 0;
var fbcontainer=””;
var fbid = ”;
var fb_script=document.createElement(‘script’);
fb_script.text= “(function(d, s, id) {var js, fjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) return;js = d.createElement(s); js.id = id;js.src=”https://connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9″;fjs.parentNode.insertBefore(js, fjs);}(document, ‘script’, ‘facebook-jssdk’));”;
var fmain = $(“.sr2309877”);
//alert(x+ “-” + url);
var fdiv = ‘

‘;
//console.log(fdiv);
//$(fb_script).appendTo(fmain);
$(fdiv).appendTo(fmain);
function fillElementWithAd($el, slotCode, size, targeting){
if (typeof targeting === ‘undefined’) {
targeting = {};
} else if ( Object.prototype.toString.call( targeting ) !== ‘[object Object]’ ) {
targeting = {};
}
var elId = $el.attr(‘id’);
//console.log(“elId:” + elId);
googletag.cmd.push(function(){
var slot = googletag.defineSlot(slotCode, size, elId);
for (var t in targeting){
slot.setTargeting(t, targeting[t]);
}
slot.addService(googletag.pubads());
googletag.display(elId);
//googletag.pubads().refresh([slot]);
});
}
$(document).delegate(“button[id^=’mf’]”, “click”, function(){
fbcontainer=””;
fbid = ‘#’ + $(this).attr(‘id’);
var sr = fbid.replace(“#mf”, “.sr”);
$(fbid).parent().children(sr).toggle();
fbcontainer = $(fbid).parent().children(sr).children(“.fb-comments”).attr(“id”);
});

function onPlayerStateChange(event){
var ing, fid;
//console.log(event + “—player”);
$(‘iframe[id*=”video-“]’).each(function(){
_v = $(this).attr(‘id’);
//console.log(“_v: ” + _v);
if(_v != event){
//console.log(“condition match”);
ing = new YT.get(_v);
if(ing.getPlayerState()==’1′){
ing.pauseVideo();
}
}
});
$(‘div[id*=”video-“]’).each(function(){
_v = $(this).attr(‘id’);
//console.log(“_v: ” + _v + ” event: ” + event);
if(_v != event){
//jwplayer(_v).play(false);
}
});
}
function onYouTubePlay(vid, code, playDiv,vx, pvid){
if (typeof(YT) == ‘undefined’ || typeof(YT.Player) == ‘undefined’) {
var tag = document.createElement(‘script’);
tag.src = “https://www.youtube.com/iframe_api”;
var firstScriptTag = document.getElementsByTagName(‘script’)[0];
firstScriptTag.parentNode.insertBefore(tag, firstScriptTag);
window.onYouTubePlayerAPIReady = function() {
onYouTubePlayer(vid, code, playDiv,vx, pvid);
};
}else{onYouTubePlayer(vid, code, playDiv,vx, pvid);}
}
function onYouTubePlayer(vid, code, playDiv,vx, pvid){
//console.log(playDiv + “Get Youtue ” + vid);
//$(“#”+vid).find(“.playvideo-“+ vx).hide();
var player = new YT.Player(playDiv , {
height: ‘450’,
width: ‘100%’,
videoId:code,
playerVars: {
‘autoplay’: 1,
‘showinfo’: 1,
‘controls’: 1
},
events: {
‘onStateChange’: function(event){
onPlayerStateChange(event.target.a.id);
}
}
});
$(“#video-“+vid).show();
}
function kalturaPlayerAPIReady(code, playDiv,pvid){
var dt=new Date;
var nt=dt.getTime();
var vtitle = “”;
pre_roll = “https://pubads.g.doubleclick.net/gampad/ads?sz=640×480&iu=/11440465/Zeenews_English_Video/Zeenews_English_Preroll&tfcd=0&npa=0&sz=640×480&gdfp_req=1&output=vast&unviewed_position_start=1&env=vp&impl=s&description_url=”+vtitle+”&correlator=”+nt;

var sources ={};
var config = {
targetId: playDiv,
provider: {
partnerId: 2504201
},
playback: {
pictureInPicture : true,
autoplay: true
},
advertising: {
adBreaks: [{
position: 0,
ads: [{
url: [pre_roll]
}]
}]
},
plugins: {
ima: {
adsResponse: “”
}
}
}
var kalturaPlayer = KalturaPlayer.setup(config);
if(kalturaPlayer){
kalturaPlayer.reset();
}
var videoUrl = code;
var mediaid = ‘”zn’ + pvid + ‘”‘;
sources = {
hls: [{
id: mediaid,
url: videoUrl,
mimetype: “application/x-mpegURL”
}]
}
kalturaplayerSetup(kalturaPlayer, sources);
if (typeof kalturaPlayer !== ‘undefined’) {
doRegisterEvents(kalturaPlayer);
}
}
function kalturaplayerSetup(kalturaPlayer, playbackType){
kalturaPlayer.setMedia({
plugins: {},
sources: playbackType
});
}

function doRegisterEvents(kalturaPlayer) {
/* player event*/
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAY, playEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PAUSE, pauseEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAYBACK_ENDED, playbackEndedEvent);

/* ad event */
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_STARTED, adStartedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_COMPLETED, adCompletedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_SKIPPED, adSkippedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_CLICKED,adClicked);
}
var vlabel = “https://zeenews.india.com”+$(this).attr(“video-path”);
var isVideoPlayed = false;
var isAdSkippedCompleted = false;

function adStartedEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adstarted’, { ‘event_category’: videotype, ‘event_label’: vlabel});
gtag(‘event’, ‘Play’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isVideoPlayed = true;
isAdSkippedCompleted = true;
}

function adCompletedEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adcompleted’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isAdSkippedCompleted = true;
}

function adSkippedEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adskipped’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isAdSkippedCompleted = true;
}

function adClicked(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adclicked’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}

function playbackEndedEvent(event){
var videotype = “zee english video”;
gtag(‘event’, ‘Complete’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}

function playEvent(event) {
var videotype = “zee english video”;

if((isVideoPlayed) && (isAdSkippedCompleted)){
isAdSkippedCompleted = false;
}else if((isVideoPlayed)){
gtag(‘event’, ‘resume’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}else{
gtag(‘event’, ‘Play’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isVideoPlayed = true;
}
}

function pauseEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Pause’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}

function AdloadEvent(event) {
var videotype = “zee english video”;
gtag(“event”, “kaltura_adloaded”, { “event_category”: videotype, “event_label”: vlabel});
}

function AdProgressEvent(event) {
var videotype = “zee english video”;
gtag(“event”, “kaltura_adprogress”, { “event_category”: videotype, “event_label”: vlabel});
}

function adPausedEvent(event) {
var videotype = “zee english video”;
gtag(“event”, “kaltura_adpaused”, { “event_category”: videotype, “event_label”: vlabel});
}
/* End of Kaltura player function code */

$(document).delegate(“div[id^=’play’]”, “click”, function(){
//console.log($(this).attr(“id”));
//console.log($(this).attr(“video-source”));
//console.log($(this).attr(“video-code”));
var isyoutube = $(this).attr(“video-source”);
var vurl = $(this).attr(“video-path”);
var vid = $(this).attr(“id”);
$(this).hide();
var pvid = $(this).attr(“newsid”);
var vx = $(this).attr(“id”).replace(‘play-‘,”);
var vC = $(this).attr(“video-code”);
var playDiv = “video-” + vid + “-” + pvid;
if(isyoutube ==’No’){
kalturaPlayerAPIReady(vC, playDiv,pvid);
}else{
onYouTubePlay(vid, vC, playDiv,vx, pvid);
}
});
$(document).delegate(“div[id^=’ptop’]”, “click”, function(){
var vid = $(this).attr(“id”).replace(‘ptop’,”);
$(this).hide();
var pvid = $(this).attr(“newsid”);
var vurl = $(this).attr(“video-path”);
//console.log($(this).attr(“id”) + “–” + vid);
//console.log($(this).parent().children().find(‘#play-‘+vid).attr(“video-source”));
//console.log($(this).parent().children().find(‘#play-‘+vid).attr(“video-code”));
var isyoutube = $(this).parent().children().find(‘#play-‘+vid).attr(“video-source”);
var vC = $(this).parent().children().find(‘#play-‘+vid).attr(“video-code”);
var playDiv = “mvideo-play-” + vid + “-” + pvid;
if(isyoutube ==’No’){
//console.log(jwplayer($(this).attr(“id”)).getState());
kalturaPlayerAPIReady(vC, playDiv,pvid);

}else{
onYouTubePlay($(this).attr(“id”), vC, playDiv, vid, pvid);
}
});

var nxti = 3;
var ci = 1;
var nxti_1 = 6;
var nxti_2 = 9;
var nxti_3 = 12;
if($.autopager==false){
var use_ajax = false;
/*var disqus_shortname=”zeehindi”;
var disqus_identifier; //made of post id and guid
var disqus_url; //post permalink

function loadDisqus(source, identifier, url, nid) {

if (window.DISQUS) {
//alert(“if”);
jQuery(‘

‘).insertAfter(source);
jQuery(‘#disqus_thread’).insertAfter(source); //append the HTML after the link
//if Disqus exists, call it’s reset method with new parameters
DISQUS.reset({
reload: true,
config: function () {
this.page.identifier = identifier;
this.page.url = url;
}
});
}else{
jQuery(‘

‘).insertAfter(source);
disqus_identifier = identifier; //set the identifier argument
disqus_url = url; //set the permalink argument

//append the Disqus embed script to HTML
var dsq = document.createElement(‘script’); dsq.type=”text/javascript”; dsq.async = true;
dsq.src=”http://” + disqus_shortname + ‘.disqus.com/embed.js’;
jQuery(‘head’).append(dsq);
}
};*/
/*$(‘.disqusOn’).live( “click”, notify );
function notify() {
identifier = $(this).attr(‘id’);
dUrl = $(this).attr(‘disqus-url’);
source = $(this).parent();
loadDisqus(jQuery(this), identifier, dUrl);
}*/
function loadshare(curl){
history.replaceState(” ,”, curl);
if(window.OBR){
window.OBR.extern.researchWidget();
}
//console.log(“loadshare Call->” + curl);
//$(‘html head’).find(‘title’).text(“main” + nxtTitle);
if(_up == false){
var cu_url = curl;
gtag(‘config’, ‘UA-2069755-1’, {‘page_path’: cu_url });

if(window.COMSCORE){
window.COMSCORE.beacon({c1: “2”, c2: “9254297”});
var e = Date.now();
$.ajax({
url: “/marathi/news/zscorecard.json?” + e,
success: function(e) {}
})
}
//console.log(‘ga:’+r);
/*(function () {
var ga = document.createElement(‘script’); ga.type=”text/javascript”; ga.async = true;
ga.src = (‘https:’ == document.location.protocol ? ‘https://’ : ‘http://’) + ‘stats.g.doubleclick.net/dc.js’;
var s = document.getElementsByTagName(‘script’)[0]; s.parentNode.insertBefore(ga, s);
})();*/
//console.log(“loadshare Call”);
}
}
if(use_ajax==false) {
//console.log(‘getting’);
var view_selector=”div.center-section”; // + settings.view_name; + ‘.view-display-id-‘ + settings.display;
var content_selector = view_selector; // + settings.content_selector;
var items_selector = content_selector + ‘ > div.rep-block’; // + settings.items_selector;
var pager_selector=”div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix”; // + settings.pager_selector;
var next_selector=”div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix > a:last”; // + settings.next_selector;
var auto_selector=”div.tag-block”;
var img_location = view_selector + ‘ > div.rep-block:last’;
var img_path=”

Loading

“; //settings.img_path;
//var img = ‘

‘ + img_path + ‘

‘;
var img = img_path;
//$(pager_selector).hide();
//alert($(next_selector).attr(‘href’));
var x = 0;
var url=””;
var prevLoc = window.location.pathname;
var circle = “”;
var myTimer = “”;
var interval = 30;
var angle = 0;
var Inverval = “”;
var angle_increment = 6;
var handle = $.autopager({
appendTo: content_selector,
content: items_selector,
runscroll: maindiv,
link: next_selector,
autoLoad: false,
page: 0,
start: function(){
$(img_location).after(img);
circle = $(‘.center-section’).find(‘#green-halo’);
myTimer = $(‘.center-section’).find(‘#myTimer’);
angle = 0;
Inverval = setInterval(function (){
$(circle).attr(“stroke-dasharray”, angle + “, 20000”);
//myTimer.innerHTML = parseInt(angle/360*100) + ‘%’;
if (angle >= 360) {
angle = 1;
}
angle += angle_increment;
}.bind(this),interval);
},
load: function(){
$(‘div.loading-block’).remove();
clearInterval(Inverval);
//$(‘.repeat-block > .row > div.main-rhs2309877’).find(‘div.rhs2309877:first’).clone().appendTo(‘.repeat-block >.row > div.main-rhs’ + x);
$(‘div.rep-block > div.main-rhs2309877 > div:first’).clone().appendTo(‘div.rep-block > div.main-rhs’ + x);
$(‘.center-section >.row:last’).before(‘

Next Story

‘);
//$(“.main-rhs” + x).theiaStickySidebar();
var fb_script=document.createElement(‘script’);
fb_script.text= “(function(d, s, id) {var js, fjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) return;js = d.createElement(s); js.id = id;js.src=”https://connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9″;fjs.parentNode.insertBefore(js, fjs);}(document, ‘script’, ‘facebook-jssdk’));”;
var fmain = $(“.sr”+ x);
//alert(x+ “-” + url);
var fdiv = ‘

‘;
//$(fb_script).appendTo(fmain);
$(fdiv).appendTo(fmain);
FB.XFBML.parse();
var $dfpAd = $(‘.center-section’).children().find(“#ad-“+ x);
xp = “#star”+x;

//var $dfpAdrhs = $(‘.main-rhs’ + x).children().find(‘.adATF’).empty().attr(“id”, “ad-300-” + x); //$(‘.content-area > .main-article > .row > .main-rhs’+x).find(‘#ad-300-‘ + x);
//var $dfpAdrhs2 = $(‘.main-rhs’ + x).children().find(‘.adBTF’).empty().attr(“id”, “ad-300-2-” + x);//$(‘.content-area > .main-article > .row > .main-rhs’+x).find(‘#ad-300-2-‘ + x);
//var $dfpMiddleAd = $(‘.content-area > .main-article > .row’).find(‘#ar’+x).find(‘#ad-middle-‘ + x).empty();
//fillElementWithAd($dfpAdrhs, ‘/11440465/Zeenews_English_Web/Zeenews_English_AS_ATF_300x250’, [[300, 250], [300, 600]], {});
//fillElementWithAd($dfpAdrhs2, ‘/11440465/Zeenews_English_Web/Zeenews_English_AS_BTF_1_300x250’, [300, 250], {});
//fillElementWithAd($dfpMiddleAd, ‘/11440465/Zeenews_Hindi_Article_Middle_300x250_BTF’, [300, 250], {});
var instagram_script=document.createElement(‘script’);
instagram_script.defer=”defer”;
instagram_script.async=”async”;
instagram_script.src=”https://platform.instagram.com/en_US/embeds.js”;

/*var outbrain_script=document.createElement(‘script’);
outbrain_script.type=”text/javascript”;
outbrain_script.async=”async”;
outbrain_script.src=”https://widgets.outbrain.com/outbrain.js”;
var Omain = $(“#outbrain-“+ x);
//alert(Omain + “–” + $(Omain).length);

$(Omain).after(outbrain_script);
var rhs = $(‘.main-article > .row > div.article-right-part > div.rhs2309877:first’).clone();
$(rhs).find(‘.ad-one’).attr(“id”, “ad-300-” + x).empty();
$(rhs).find(‘.ad-two’).attr(“id”, “ad-300-2-” + x).empty();
//$(‘.main-article > .row > div.article-right-part > div.rhs2309877:first’).clone().appendTo(‘.main-article > .row > div.main-rhs’ + x);
$(rhs).appendTo(‘.main-article > .row > div.main-rhs’ + x); */

setTimeout(function(){

var twit = $(“div.field-name-body”).find(‘blockquote[class^=”twitter”]’).length;
var insta = $(“div.field-name-body”).find(‘blockquote[class^=”instagram”]’).length;
if(twit==0){twit = ($(“div.field-name-body”).find(‘twitterwidget[class^=”twitter”]’).length);}
if(twit>0){
if (typeof (twttr) != ‘undefined’) {
twttr.widgets.load();

} else {
$.getScript(‘https://platform.twitter.com/widgets.js’);
}
//$(twit).addClass(‘tfmargin’);
}
if(insta>0){
$(‘.content > .left-block:last’).after(instagram_script);
//$(insta).addClass(‘tfmargin’);
window.instgrm.Embeds.process();
}
}, 1500);
}
});
/*$(“#loadmore”).click(function(){
x=$(next_selector).attr(‘id’);
var url = $(next_selector).attr(‘href’);
disqus_identifier=”ZNH” + x;
disqus_url = url;
handle.autopager(‘load’);
history.pushState(” ,”, url);
setTimeout(function(){
//twttr.widgets.load();
//loadDisqus(jQuery(this), disqus_identifier, disqus_url);
}, 6000);
});*/

/*$(“button[id^=’mf’]”).live(“click”, disqusToggle);
function disqusToggle() {
console.log(“Main id: ” + $(this).attr(‘id’));
}*/
$(document).delegate(“button[id^=’mf’]”, “click”, function(){
fbcontainer=””;
fbid = ‘#’ + $(this).attr(‘id’);
var sr = fbid.replace(“#mf”, “.sr”);

//console.log(“Main id: ” + $(this).attr(‘id’) + “Goodbye!jQuery 1.4.3+” + sr);
$(fbid).parent().children(sr).toggle();
fbcontainer = $(fbid).parent().children(sr).children(“.fb-comments”).attr(“id”);
//console.log(fbcontainer);
//var commentsContainer = document.getElementById(fbcontainer);
//commentsContainer.innerHTML = ”;

});
/************Player Code ***********/
var title, imageUrl, description, author, shortName, identifier, timestamp, summary, newsID, nextnews;
var previousScroll = 0;
//console.log(“prevLoc” + prevLoc);
$(window).scroll(function(){
var last = $(auto_selector).filter(‘:last’);
var lastHeight = last.offset().top ;
//st = $(layout).scrollTop();
//console.log(“st:” + st);
var currentScroll = $(this).scrollTop();
if (currentScroll > previousScroll){
_up = false;
} else {
_up = true;
}
previousScroll = currentScroll;
//console.log(“_up” + _up);

var cutoff = $(window).scrollTop() + 64;
//console.log(cutoff + “**”);
$(‘div[id^=”row”]’).each(function(){
//console.log(“article” + $(this).children().find(‘.left-block’).attr(“id”) + $(this).children().find(‘.left-block’).attr(‘data-url’));
if($(this).offset().top + $(this).height() > cutoff){
//console.log(“$$” + $(this).children().find(‘.left-block’).attr(‘data-url’));
if(prevLoc != $(this).children().find(‘.left-block’).attr(‘data-url’)){
prevLoc = $(this).children().find(‘.left-block’).attr(‘data-url’);
$(‘html head’).find(‘title’).text($(this).children().find(‘.left-block’).attr(‘data-title’));
$(‘meta[name=description]’).attr(“content”,$(this).children().find(‘.left-block’).attr(‘data-summary’));
$(‘meta[name=keywords]’).attr(“content”,$(this).children().find(‘.left-block’).attr(‘data-keyword’));
$(‘meta[name=news_keywords]’).attr(“content”,$(this).children().find(‘.left-block’).attr(‘data-keyword’));

pSUPERFLY.virtualPage(prevLoc,$(this).children().find(‘.left-block’).attr(‘data-title’));
//console.log(“Summary: ” + $(this).children().find(‘.left-block’).attr(‘data-summary’));
//console.log(“Keyword: ” + $(this).children().find(‘.left-block’).attr(‘data-keyword’));
//history.pushState(” ,”, prevLoc);
loadshare(prevLoc);
}
return false; // stops the iteration after the first one on screen
}
});
if(lastHeight + last.height() < $(document).scrollTop() + $(window).height()){
//console.log("**get");
url = $(next_selector).attr('href');
x=$(next_selector).attr('id');
//console.log("x:" + x);
//handle.autopager('load');

/*setTimeout(function(){
//twttr.widgets.load();
//loadDisqus(jQuery(this), disqus_identifier, disqus_url);
}, 6000);*/
}
//lastoff = last.offset();
//console.log("**" + lastoff + "**");
});
//$( ".content-area" ).click(function(event) {
// console.log(event.target.nodeName);
//});

/*$( ".comment-button" ).live("click", disqusToggle);
function disqusToggle() {
var id = $(this).attr("id");
$("#disqus_thread1" + id).toggle();
};*/
//$(".main-rhs2309877").theiaStickySidebar();
var prev_content_height = $(content_selector).height();
//$(function() {
var layout = $(content_selector);
var st = 0;
///});

}
}
});

/*}
};*/
})(jQuery);

(function() {
var reset_scroll;

$(function() {
return $(“[data-sticky_column]”).stick_in_parent({
parent: “[data-sticky_parent]”
});
});

reset_scroll = function() {
var scroller;
scroller = $(“body,html”);
scroller.stop(true);
if ($(window).scrollTop() !== 0) {
scroller.animate({
scrollTop: 0
}, “fast”);
}
return scroller;
};

window.scroll_it = function() {
var max;
max = $(document).height() – $(window).height();
return reset_scroll().animate({
scrollTop: max
}, max * 3).delay(100).animate({
scrollTop: 0
}, max * 3);
};

window.scroll_it_wobble = function() {
var max, third;
max = $(document).height() – $(window).height();
third = Math.floor(max / 3);
return reset_scroll().animate({
scrollTop: third * 2
}, max * 3).delay(100).animate({
scrollTop: third
}, max * 3).delay(100).animate({
scrollTop: max
}, max * 3).delay(100).animate({
scrollTop: 0
}, max * 3);
};

$(window).on(“resize”, (function(_this) {
return function(e) {
return $(document.body).trigger(“sticky_kit:recalc”);
};
})(this));

}).call(this);

body{overflow:hidden}
.article-tag-link{margin:5px 0px;padding:0px;font-size:14px;font-weight:700;color:#e21727;text-transform:uppercase;}
.article-tag-link a{color:#e21727;}
.article-widgetpara{font-size:38px;color:#191c20;line-height:normal;margin-bottom:10px;}
.article-widgetpara a{font-size:38px;color:#191c20;line-height:normal;}
.widget-image-block{position:relative;height:270px;overflow:hidden;}
.stry_ldmore{width:100%;position:absolute;bottom:0px;text-align:center;display:block;}
.stry_fdr{bottom:0;background:linear-gradient(to bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 1) 100%) repeat scroll 0 0 rgba(0, 0, 0, 0);height:200px;position:absolute;width:100%;}
.stry_shwmre{background:#2089ff;color:#FFF;cursor:pointer;padding:10px 20px;text-align:center;position:relative;display:inline-block;left:50%;margin-left:-83px;border-top-left-radius:5px;border-top-right-radius: 5px;}
.stry_shwmre:hover{background:#1581f9}
.wid-line{border-bottom:1px solid #2089ff; position:absolute;bottom:0;width:100%;}
.widget-vs{padding-left:inherit;padding-right:inherit;}
.white-txt{color:#FFF !important;}
.article-head-block p{font-size:18px;color:#444;line-height:26px}
.play-b{width:70px;height:70px;top:50%;left:50%;position:absolute;z-index:1009;cursor:pointer;margin-left:-35px;margin-top:-35px;bottom:inherit;right:inherit;}

.kaltura-player-container{position: relative; top: 0px; right: 0; bottom: 0; left: 0; width: 100%; height: 500px;}
.playkit-player-gui{display:block !important;}

function on_load_google_ad(){
var inad1, inad2 = ”;
googletag.cmd.push(function() {
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_ATF_970x90’, [[970, 90], [970, 250], [970, 66], [728, 90]], ‘div-gpt-ad-1504525832454-0’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Heart Diseases”,”Psoriasis”,”Health”]));
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_ATF_300x250’, [[300, 600], [300, 250]], ‘div-article-rhs-atf-ad’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Heart Diseases”,”Psoriasis”,”Health”]));
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_BTF_1_300x250’, [300, 250], ‘div-gpt-ad-1504525832454-2’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Heart Diseases”,”Psoriasis”,”Health”]));
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_OOP_1x1’, [1, 1], ‘div-gpt-ad-1504526235866-6’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Heart Diseases”,”Psoriasis”,”Health”]));
var inarticle1 = document.getElementById(‘div-gpt-ad-AS-Inarticle-1’);
if (typeof(inarticle1) != ‘undefined’ && inarticle1 != null)
{
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_Inarticle_1_300x250’, [[300, 250]], ‘div-gpt-ad-AS-Inarticle-1’).addService(googletag.pubads().setTargeting(“category”, [“Health”,”Heart Diseases”,”Psoriasis”,”Health”]));
inad1 = “true”;
}
var inarticle2 = document.getElementById(‘div-gpt-ad-AS-Inarticle-2’);
if (typeof(inarticle2) != ‘undefined’ && inarticle2 != null)
{
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_Inarticle_2_300x250’, [[300, 250]], ‘div-gpt-ad-AS-Inarticle-2’).addService(googletag.pubads().setTargeting(“category”, [“Health”,”Heart Diseases”,”Psoriasis”,”Health”]));
inad2 = “true”;
}
googletag.pubads().disableInitialLoad();
googletag.pubads().enableAsyncRendering();
googletag.pubads().set(‘page_url’,’https://zeenews.india.com/’);
googletag.pubads().enableSingleRequest();
googletag.pubads().collapseEmptyDivs();
googletag.enableServices();
});
googletag.cmd.push(function() { googletag.display(‘div-article-rhs-atf-ad’); });
googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1504525832454-0’); });
googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1504525832454-2’); });
googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1504526235866-6’); });

}
on_load_google_ad();
function sendAdserverRequest() {
try {
if (pbjs && pbjs.adserverRequestSent) return;
googletag.cmd.push(function() {
googletag.pubads().refresh();
});
} catch (e) {

googletag.cmd.push(function() {
googletag.pubads().refresh();
});
}
}
setTimeout(function() { sendAdserverRequest(); }, 5000);

function on_load_fb_twitter_widgets(){
(function(d, s, id) {
var js, fjs = d.getElementsByTagName(s)[0];
if (d.getElementById(id)) return;
js = d.createElement(s); js.id = id;
js.src = “https://connect.facebook.net/en_US/sdk.js#xfbml=1&version=v2.9”;
fjs.parentNode.insertBefore(js, fjs);
}(document, ‘script’, ‘facebook-jssdk’));

window.twttr = (function(d, s, id) {
var js, fjs = d.getElementsByTagName(s)[0],
t = window.twttr || {};
if (d.getElementById(id)) return t;
js = d.createElement(s);
js.id = id;
js.src = “https://platform.twitter.com/widgets.js”;
fjs.parentNode.insertBefore(js, fjs);
t._e = [];
t.ready = function(f) {

t._e.push(f);
};
return t;
}(document, “script”, “twitter-wjs”));
}

//setTimeout(function() { on_load_google_ad(); }, 5000);
setTimeout(function() {
on_load_fb_twitter_widgets();
}, 5000);

Source link

Leave a Reply

Your email address will not be published. Required fields are marked *